Clinical Studies on S-6436

Studies on Ribonuclease S

Specific regions of the polypeptide sequence of pancreatic ribonuclease have been altered by chemical modification and by limited proteolytic digestion in attempts to implicate specific covalent portions of the molecule in the structure and stabilization of the active center. Digestion of the native molecule with trypsin at elevated temperatures has been shown to remove portions of the chain wi...

Clinical studies on progressive retinal atrophy in 31 dogs

During a 2-year period, 31 cases of a hereditary retinal degeneration in dogs bred in India were found mainly suspected for progressive retinal atrophy (PRA) with typical history of initial nyctalopia followed by hemeralopia. Out of 31 PRA suspected dogs, 8 dogs (26%) were from the age group of 1-5 years, 15 (48%) 6-10 years and the rest (26%) 11-15 years. The most predominant breed was Spitz (...

Clinical and Epidemiological Studies of Wegener ́s Granulomatosis

Approaches on Arthropod ́s Molecular Systematics Studies

Arthropods in general, and the fruit fly, Drosophila melanogaster (Figure. 1A), in particular, have traditionally served as models in developmental biology for understanding morphology or for biomedical reasons providing a key to the development of studies on vertebrates, as an important model of genetic organism. All the fundamentals of classical genetics were built largely through studies on ...

Immunological studies on Burkitt ' s lymphoma Leukemia

A FEW years ago, it became clear, in the progress of experimental tumor immunology'-7 that all virusinduced tumors carry a common, group-specific transplantation antigen, capable of inducing rejection reactions in syngeneic hosts. The question arose whether it would be possible to utilize this fact for the search after possibly similar, virally determined transplantation antigens in tumors of u...